DuraGen Plus™ Adhesion Barrier Matrix

Designed for the repair and restoration of dural defects in cranial and spinal procedures, and as an adhesion barrier for the reduction of peridural fibrosis.

DuraGen Plus™, enhanced performance and design for restoration of dural defects.

  • Conforms like normal soft tissue, moulding easily to complex surfaces of the brain and spinal dura.
  • 12.5 cm x 17.5 cm size for use in large dural defects (e.g. decompressive hemicraniectomy).
  • Engineered porosity (uniform pore structure) facilitates cell ingrowth.
  • Increased tensile strength for superior handling.

DuraGen Plus™ inhibits fibrosis and prevents adhesion.

  • The Adhesion Barrier Matrix provides a physical barrier between the dura and overlying tissues.
  • The Adhesion Barrier Matrix remains in place during active healing and is fully resorbed after healing is complete.
  • Simple sutureless technique that allows for precise placement in both spinal and cranial procedures.

DuraGen Plus™, the result of 30 years of innovation.

  • Unmatched history of safety and effectiveness.
  • Proven protection against CSF leakage with sutureless closure.
  • No reported foreign body reactions or immune rejection.
  • Integra’s Ultra Pure Collagen™ has been used by surgeons in over 10 million implant procedures.
  • Integra’s Ultra Pure Collagen™ is used to manufacture products for some of the world’s largest medical device companies.

Intended Use

DuraGen® Plus matrix is an absorbable implant designed for the repair and restoration of dural defects and as an adhesion barrier for the reduction of peridural fibrosis.

Regulatory and Legal information

INTEGRA LifeSciences Corporation
1100 Campus Road,
Princeton, New Jersey 08540 • USA

Integra LifeSciences Services (France) SAS
Immeuble Sequoia 2 • 97 allée Alexandre Borodine
Parc technologique de la Porte des Alpes
69800 Saint Priest • FRANCE


Availability of these products might vary from a given country or region to another, as a result of specific local regulatory approval or clearance requirements for sale in such country or region.

  • Non contractual document. The manufacturer reserves the right, without prior notice, to modify the products in order to improve their quality.
  • Warning: Applicable laws restrict these products to sale by or on the order of a physician.
  • Consult product labels and inserts for any indication, contraindications, hazards, warnings, precautions, and instructions for use.

Products mentioned in this document are CE class III devices. Please contact Integra customer service should you need any additional information on devices classification. All the medical devices mentioned on this document are CE marked in accordance with the applicable European laws, unless specifically identified as “NOT CE MARKED”.

DuraGen, Integra and the Integra logo are registered trademarks of Integra Lifesciences Corporation in the United States and/or other countries. Ultra Pure Collagen is a trademark of Integra LifeSciences Corporation or its subsidiaries in the United States and/or other countries.
©2022 Integra LifeSciences Corporation. All rights reserved.
Last modification date: 09/2022. 2973174-1-EN
Document for use in Europe, Middle-East & Africa only

For more information, please contact your Integra representative.
For complete product information, please consult product labels and inserts for any indications, contraindications, hazards, warnings, precautions, and instructions for use.